Indicators of Thyroid Hormone Disruption
Several classes of environmental contaminants have been identified as having the ability to alter thyroid hormone signaling. Our lab is working identify sensitive indicators of thyroid hormone disruption in the fathead minnow, a model organism frequently used in the screening of endocrine disrupting compounds. In addition, we are currently working to determine how exposures to model thyroid hormone disruptors alter not only growth and development, but also reproductive and immune function. We are particularly interested in how impaired thyroid function during the earliest stages of development lead to permanent alterations in reproductive endocrinology and immunity.